منابع مشابه
Ocular Angiogenesis
1Department of Health Informatics, Federal University of São Paulo, Paulista School of Medicine, 04023-062 São Paulo, SP, Brazil 2Department of Biochemistry, Federal University of São Paulo, Paulista School of Medicine, 04039-032 São Paulo, SP, Brazil 3Department of Biochemistry, University of São Paulo, 05508-000 São Paulo, SP, Brazil 4Department of Ophthalmology, Federal University of São Pau...
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Ocular neovascularization can affect almost all the tissues of the eye: the cornea, the iris, the retina, and the choroid. Pathological neovascularization is the underlying cause of vision loss in common ocular conditions such as diabetic retinopathy, retinopathy of prematurity and age-related macular neovascularization. Glycosylation is the most common covalent posttranslational modification o...
متن کاملGene therapy for ocular angiogenesis.
Ocular neovascularization is a central feature of diabetic retinopathy and age-related macular degeneration. These conditions are the major causes of blindness in the developed world. Current treatments are of limited efficacy and associated with significant adverse effects. Characterization of the molecular and cellular events involved in angiogenesis has led to the identification of a number ...
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Disruption of the quiescent state of blood vessels in the retina leads to aberrant vasopermeability and angiogenesis, the major causes of vision loss in diabetic retinopathy. Prolactin is expressed throughout the retina, where it is proteolytically cleaved to vasoinhibins, a family of peptides (including the 16-kDa fragment of prolactin) with potent antiangiogenic, vasoconstrictive, and antivas...
متن کاملEndothelial Tip Cells in Ocular Angiogenesis
Endothelial tip cells are leading cells at the tips of vascular sprouts coordinating multiple processes during angiogenesis. In the developing retina, tip cells play a tightly controlled, timely role in angiogenesis. In contrast, excessive numbers of tip cells are a characteristic of the chaotic pathological blood vessels in proliferative retinopathies. Tip cells control adjacent endothelial ce...
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ژورنال
عنوان ژورنال: Journal of Ophthalmology
سال: 2015
ISSN: 2090-004X,2090-0058
DOI: 10.1155/2015/892043